Certificate of Analysis and Data Sheet

Source:
E.coli

Catalog No.
PRO-308

Presentation:

100痞 purified human Transglutaminase II protein at 100ug/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.

Description :

Transglutaminase-II is an enzyme from different species containing 685-691 amino acids with
77-85kDa molecular mass, encoded by messages of 3.6kb to 3.9kb.
TGASE-II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.

Application And Suggested Dilutions:

?ELISA
?Inhibition Assays
?Western Blotting
?Biological assays

Characterization:

On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at
101-109kDa.

Activity:

This protein has biological transglutaminase activities.

Storage & Stability:

Store vial at -20⁰C to -80⁰C. When stored at the recommended temperature, this protein is stable for 12 months.

Uses:

This material is offered by ProSpec-Tany TechnoGene for research, laboratory or further manufacturing purposes.

Gene:

Name:TGM2

Protein synonyms/aliases:

Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13)
    (Tissuetransglutaminase)
    (TGase C)
    (TGC)
    (TG(C))
    (Tranglutaminase-2)
    (TGase-H).

Protein Family:

Belongs to the transglutaminase family.

Protein Domains:

Domains:
•IPR001102   Protein-glutamine gamma-glutamyltransferase
•IPR001102   Protein-glutamine gamma-glutamyltransferase
•IPR002931   Transglutaminase-like
•IPR001102   Protein-glutamine gamma-glutamyltransferase

Protein links:

Precursor- Protein structure and amino acid sequence:

Latest Publications:

1. Leukocyte Transglutaminase 2 Expression Limits Atherosclerotic Lesion Size.
Arterioscler Thromb Vasc Biol 2006 Jan 12;
2. The role of transglutaminase-2 and its substrates in human diseases.
Front Biosci 2006 May 1;11:1758-73
3. Alteration of Rb binding to HPV 18 E7 modified by transglutaminase 2 with different type of polyamines.
Front Biosci 2006 May 1;11:1540-8
4. Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain.
Neurochem Res 2005 Oct;30(10):1245-55
5. Matrix changes induced by transglutaminase 2 lead to inhibition of angiogenesis and tumor growth.
Cell Death Differ 2005 Nov 18;
6. Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas.
Mol Cancer Ther 2005 Sep;4(9):1293-302

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中華民國95年06月06日更新