Certificate of Analysis and Data Sheet

Source:
E.coli

Catalog No.
PRO-370

Description :

Calmodulin (CaM) is an intracellular receptor protein for Ca²⁺-ions.
It activates the myosin light chain kinase which is the catalyst of myosin phosphorylation.CaM participates in the activation of enzymes such as cyclic nucleotide- dependent phosphodiesterase, calcineurin, ATPase, Myosin Light Chain Kinases, and CAM kinase.

Formulation:

Human Calmodulin protein at 1mg/ml in in 20mM HEPES-KOH, pH7, 50mM NaCl, 1mM EDTA and 1mM DTT.

Application And Suggested Dilutions:

?ELISA
?Inhibition Assays
?Western Blotting

Activity:

Assayed for calcium binding and activation of MLCK.

Storage & Stability:

Store vial at -20⁰C to -80⁰C. When stored at the recommended temperature, this protein is stable for 12 months.

Legal Consideration:

This material is offered by ProSpec-TechnoGene for research, laboratory or further manufacturing purposes

Gene:

Name:CALM1
Synonyms:CALM, CAM, CAM1
andName:CALM2
Synonyms:CAM2, CAMB
andName:CALM3
Synonyms:CAM3, CAMC, CAMIII

Protein synonyms/aliases:

Calmodulin (CaM).

Protein Family:

Protein Domains:

Domains:
•IPR002048   Calcium-binding EF-hand

Protein links:

Precursor- Protein structure and amino acid sequence:

Latest Publications:

1. A surface plasmon resonance sensor for substance P using gold-modified calmodulin and melittin.
Anal Sci 2005 Dec;21(12):1431-6
2. [The calmodulin inhibitor R24571 induces a short-term Ca2+ entry and a pulse-like secretion of ATP in Ehrlich ascites tumor cells]
Biofizika 2005 Nov-Dec;50(6):1055-69
3. Mapping protein interfaces by chemical cross-linking and Fourier transform ion cyclotron resonance mass spectrometry: application to a calmodulin / adenylyl cyclase 8 peptide complex.
Eur J Mass Spectrom (Chichester, Eng) 2005;11(5):525-34
4. Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is up-regulated in gastrointestinal cancers.
Cancer Res 2005 Dec 1;65(23):10725-33
5. Nuclear sequestration of beta-subunits by Rad and Rem is controlled by 14-3-3 and calmodulin and reveals a novel mechanism for Ca2+ channel regulation.
J Mol Biol 2006 Jan 6;355(1):34-46
6. Calmodulin regulation and identification of calmodulin binding region of type-3 ryanodine receptor calcium release channel.
Biochemistry 2005 Nov 15;44(45):15074-81

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中華民國95年06月06日更新