Certificate of Analysis and Data Sheet

Catalog No.
EBV-271

Source
E.coli

Description :

The mosaic protein contains fragments of HHV-4 EBNA1 nuclear protein , amino acids: (1-90),(408-498).

Purification method:

Purified by proprietary chromatographic technique.

Purity:

Protein is >95% pure as determined by 10% PAGE (coomassie staining) and RP-HPLC.

Protein conc:

1mg/ml in 50mM Tris-HCl, 10mM glutation, 60mM NaCl and 0.5% sarcosyl.

Storage:

Protein is shipped at ambient temperature. Upon arrival, Store at -20C.

Stability:

Five years frozen. One month in solution at room temperature.

Specificity:

Immunoreactive with sera of EBV-infected individuals.

Application:

Antigen in ELISA and Western blots, excellent antigen for detection of HHV-4 (EBV)- with minimal specificity problems.

Usage:

This material is offered by ProSpec-TechnoGene for research, laboratory or further evaluation purposes.

Gene:

Name:BKRF1

Protein synonyms/aliases:

Epstein-Barr nuclear antigen 1 (EBNA-1).

Protein Family:

Protein Domains:

Domains:
•IPR004186   Epstein Barr virus nuclear antigen-1, DNA-binding

Protein links:

Precursor- Protein structure and amino acid sequence:

Latest Publications:

1. Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1.
J Virol 2005 Apr;79(8):4640-50
2. Eradication of Epstein-Barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1.
Mol Ther 2005 Apr;11(4):578-90
3. In vivo dynamics of EBNA1-oriP interaction during latent and lytic replication of Epstein-Barr virus.
J Biol Chem 2004 Dec 24;279(52):54817-25
4. Multiple EBNA1-binding sites within oriPI are required for EBNA1-dependent transactivation of the Epstein-Barr virus C promoter.
Int J Oncol 2004 Sep;25(3):693-6
5. EBNA1 efficiently assembles on chromatin containing the Epstein-Barr virus latent origin of replication.
Virology 2003 Oct 25;315(2):398-408
6. Cytolytic CD4(+)-T-cell clones reactive to EBNA1 inhibit Epstein-Barr virus-induced B-cell proliferation.
J Virol 2003 Nov;77(22):12088-104

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中華民國95年06月06日更新