Certificate of Analysis and Data Sheet

Source:
Human Plasma

Catalog No.
PRO-378

Background:

Description :

Alpha 1 ACT is an early-stage acute-phase plasma protein and a serpin that preferentially inactivates chymotrypsin, cathepsin G, and chymase. Alpha-1- ACT, a serine protease inhibitor, is tightly associated with amyloid plaques in Alzheimer's disease (AD) and in normal aged human and monkey brain.
Regulation of the serine proteases and serine protease inhibitors plays an important role in neuromuscular differentiation. Prostate specific antigen (PSA), a chymotrypsin-like serine protease, is predominantly complexed to Alpha-1-ACT.

Physical Appearance:

Sterile Filtered clear solution.

Formulation:

Human Alpha-1 AntiChymotrypsin at a concentration of 0.1mg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol.

Stability:

hA1ACT although stable at 14⁰C for 1 week, should be stored desiccated below -18⁰C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze-thaw cycles.

Applications:

?ELISA
?Inhibition Assays
?Western Blotting

Usage:

Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Gene:

Name:SERPINA3
Synonyms:AACT

Protein synonyms/aliases:

Alpha-1-antichymotrypsin precursor (ACT)

Precursor's functional components:

Alpha-1-antichymotrypsin His-Pro-less .

Protein Family:

Belongs to the serpin family.

Protein Domains:

Domains:
•IPR000215   Proteinase inhibitor I4, serpin

Protein links:

Precursor- Protein structure and amino acid sequence:

Latest Publications:

1. Post-stroke dementia is associated with alpha(1)-antichymotrypsin polymorphism.
J Neurol Sci 2005 Jul 15;234 (1-2):31-6
2. Alpha-1-antichymotrypsin gene polymorphism and susceptibility to multiple system atrophy (MSA).
Brain Res Mol Brain Res 2005 Aug 18;138(2):178-81
3. Duration of alpha 1-antichymotrypsin gene activation by interleukin-1 is determined by efficiency of inhibitor of nuclear factor kappa B alpha resynthesis in primary human astrocytes.
J Neurochem 2005 Feb;92(4):730-8
4. A new promoter polymorphism in the alpha-1-antichymotrypsin gene is a disease modifier of Alzheimer's disease.
Neurobiol Aging 2005 Apr;26(4):449-53
5. mRNA expression level of estrogen-inducible gene, alpha 1-antichymotrypsin, is a predictor of early tumor recurrence in patients with invasive breast cancers.
Cancer Sci 2004 Nov;95(11):887-92
6. Allele-specific overexpression in astrocytes of an Alzheimer's disease associated alpha-1-antichymotrypsin promoter polymorphism.
Brain Res Mol Brain Res 2004 Nov 24;131(1-2):88-92

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中華民國95年06月06日更新