Certificate of Analysis and Data Sheet

Source:

Catalog No.
HOR-243

Description :

Thymosin alpha-1 acetate, also known as thymalfasin has immunoregulatory properties enhancing immune functions. Thymosin a1 has a molecular formula of C₁₂₉H₂₁₅N₃₃O₅₅ a.a. sequence of Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH and having a Mw of 3108.32.

Physical Appearance:

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation:

The protein (1mg/ml) was lyophilized with no additives.

Solubility:

It is recommended to reconstitute the lyophilized Thymosin alpha1 in sterile 18MΩ-cm H₂O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.

Stability:

Lyophilized Thymosin-a1 although stable at room temperature for 3 weeks, should be stored desiccated below -18⁰C. Upon reconstitution Thymosin a1 should be stored at 4⁰C between 2-7 days and for future use below -18⁰C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze-thaw cycles.

Purity:

Greater than 99.0% as determined by: (a) Analysis by RP-HPLC. (b) Anion-exchange FPLC. (c) Analysis by reducing and non-reducing SDS-PAGE Silver Stained.

Dimers and aggregates:

Less than 1% as determined by silver-stained SDS-PAGE gel analysis.

Endotoxin:

Less than 0.1 ng/ug (IEU/ug) of Thymosin a1.

Protein content:

Protein quantitation was carried out by two independent methods: 1. UV spectroscopy at 280 nm. 2. Analysis by RP-HPLC, using a calibrated solution of Thymosin-alpha1 as a Reference Standard.

Usage:

Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Gene:

Name:PTMA
Synonyms:TMSA

Protein synonyms/aliases:

Prothymosin alpha

Precursor's functional components:

Thymosin alpha-1 .

Protein Family:

Belongs to the pro/parathymosin family.

Protein Domains:

Domains:
•IPR004931   Prothymosin/parathymosin

Protein links:

Precursor- Protein structure and amino acid sequence:

Latest Publications:

1. Antitumor activation of peritoneal macrophages by thymosin alpha-1.
Cancer Invest 2005;23(4):316-22
2. Thymosin alpha 1 attenuates lipid peroxidation and improves fructose-induced steatohepatitis in rats.
Clin Biochem 2005 Jun;38(6):540-7
3. The efficacy and safety of thymosin alpha-1 in Japanese patients with chronic hepatitis B; results from a randomized clinical trial.
J Viral Hepat 2005 May;12(3):300-6
4. A randomized, controlled, clinical study of thymosin alpha-1 versus interferon-alpha in [corrected] patients with chronic hepatitis B lacking HBeAg in China [corrected]
J Chin Med Assoc 2005 Feb;68(2):65-72
5. Overexpression of soluble human thymosin alpha 1 in Escherichia coli.
Acta Biochim Biophys Sin (Shanghai) 2005 Feb;37(2):147-51
6. Combination therapy of thymalfasin (thymosin-alpha 1) and peginterferon alfa-2a in patients with chronic hepatitis C virus infection who are non-responders to standard treatment.
J Gastroenterol Hepatol 2004 Dec;19(12):S76-8

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中華民國95年06月06日更新