Certificate of Analysis and Data Sheet

Source:

Catalog No.
PRO-409

Description:

S100A6 also called Calcyclin has been purified by HPLC (see Kuznicki et al. (1989) Biochem. J. 263: 951-956).

Physical Appearance:

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation:

The protein was lyophilized from a concentrated solution (1mg/ml) containing no additives.

Solubility:

It is recommended to reconstitute the lyophilized S100A6 in sterile 18MΩ-cm H₂O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.

Stability:

Lyophilized S100A6 although stable at room temperature for 3 weeks, should be stored desiccated below -18⁰C. Upon reconstitution S100A6 should be stored at 4⁰C between 2-7 days and for future use below -18⁰C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze-thaw cycles.

Purity:

Greater than 90.0% as determined by:
Analysis by reducing and non-reducing SDS-PAGE Coomassie.

Applications:

Immunoblots.
Absorption.
Immunohistochemistry

Usage:

This material is offered by ProSpec-TechnoGene for research, laboratory or further evaluation purposes.

Gene:

Name:S100A6
Synonyms:CACY

Protein synonyms/aliases:

Calcyclin (Prolactin receptor associated protein)
    (PRA)
    (Growthfactor-inducible protein 2A9)
    (S100 calcium-binding protein A6)
    (MLN4).

Protein Family:

Belongs to the S-100 family.

Protein Domains:

Domains:
•IPR002048   Calcium-binding EF-hand
•IPR001751   Calcium-binding protein, S-100/ICaBP type

Related proteins:

•Recombinant Human S100b
•Recombinant Rat Calbindin D-9K
•Recombinant Human S100P
•Recombinant Human S100Z
•Recombinant Human S100A1
•Recombinant Human S100A4
•Recombinant Human S100A10
•Recombinant Human S100A11

Protein links:

Precursor- Protein structure and amino acid sequence:

Latest Publications:

1. S100A6 and CacyBP/SIP - two proteins discovered in ehrlich ascites tumor cells that are potentially involved in the degradation of beta-catenin.
Chemotherapy 2006;52(1):32-4
2. Calcium-binding proteins annexin A2 and S100A6 are sensors of tubular injury and recovery in acute renal failure.
Kidney Int 2005 Dec;68(6):2694-703
3. Binding and functional characteristics of two E-box motifs within the S100A6 (calcyclin) gene promoter.
J Cell Biochem 2005 Nov 15;
4. The role of S100A6 in pancreatic cancer development and its clinical implication as a diagnostic marker and therapeutic target.
Clin Cancer Res 2005 Nov 1;11(21):7785-93
5. Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma.
Cancer Lett 2005 Nov 8;229(1):135-48
6. Promoter hyper-methylation of calcium binding proteins S100A6 and S100A2 in human prostate cancer.
Prostate 2005 Dec 1;65(4):322-30

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中華民國95年06月06日更新